Glucose-lowering agents have a difficult prediction on the mortality of diabetes patients due to the characteristics of the disease state. There is limited data on the impact on survival these agents have. Sulfonylureas and insulin have been associated with increased risk of mortality in diabetes patients. Metformin has a lower mortality risk in patients with type 2 diabetes. In addition, the usefulness of statins for cardiovascular diseases that arise from type 2 diabetes has been highly debated.