Victoza Tested as Add-on Therapy for DKA in Type 1

A recent study has looked into whether Victoza and other drugs in its class (GLP-1 agonists) can help people with type 1 diabetes to lower their blood glucose levels and lower risk of diabetic ketoacidosis (DKA). The study, conducted by researchers at the Diabetes and Endocrinology Center of Western New York, investigated whether Victoza could reduce production […]

Where are all the new diabetes drugs?

So has pharma run out of ideas in diabetes? Not exactly. But whether its ideas will ever get to market is another question. There’s plenty of promising science in the early stages of research. Available drugs, however, work pretty well. Given the cost of development and a high bar for approval, pharma can only afford […]

A New Combination Treatment Could Become the Standard T2 Diabetes

A study in Diabetes Care showed that patients with poorly controlled type 2 diabetes who received a combination of exenatide and pioglitazone had a threefold lower rate of hypoglycemia, a one-percentage-point greater reduction in A1C and less weight gain than those in the basal-bolus insulin therapy group.

FDA Approves New Diabetes Combo LixiLan and IDegLira for T2 Diabetes

Both products, known as LixiLan and IDegLira during clinical trials, were delayed by 3 months at the U.S. Food and Drug Administration (FDA) following recommendations for approval from FDA panels back in May. And yet the FDA has approved the two new competing combination products containing fixed doses of glucagonlike-peptide 1 (GLP-1) receptor agonists and […]

Long-acting Synjardy gets FDA approval for type 2 diabetes treatment in the US

The US Food and Drug Administration (FDA) has approved the slow release form of Synjardy. Synjardy is a drug used by people with type 2 diabetes in the UK as a twice daily single pill combination therapy to lower blood sugar levels.

Joslin Diabetes – Is it Possible to Get Diabetes from Statins?

If you’re like nearly one-third of Americans over age 40, you probably take a statin. These cholesterol-lowering drugs are used for reducing risk of stroke and heart attack. They work by lowering the amount of LDL cholesterol, the so-called “bad cholesterol” in the blood. Statins also reduce inflammation around plaque in the blood vessels.

Can Statins Offset Insulin-Related Cancer Risk in T2DM?

The researchers found that the risk of cancers of the colon (males only), liver (males only), pancreas, lung (males only), and brain (males only) were increased up to nine-fold for patients treated with insulin or insulin secretagogues; the risk of prostate cancer was decreased strongly. The risks were generally decreased for patients taking statins, with […]

Trial finds type 2 diabetes drug liraglutide can affect heart rate variability

The type 2 diabetes drug liraglutide could affect heart variability in newly diagnosed people who are overweight and have heart problems, according to new research. Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist which helps control blood sugar levels and reduces post-meal hyperglycemia. The drug is marketed as Victoza and Saxenda.

Diabetes Mine – Media Matters: The Feud Over Heart Risk Lowering Diabetes Drugs

Believe it or not, some people were disappointed and underwhelmed by solid evidence that Victoza (ligratude), a medication for type 2 diabetes, reduces the risk of fatal diabetes complications. That news, based on a massive clinical trial of Novo Nordisk’s drug, was one of the mostly widely reported items from the American Diabetes Association’s recent […]

Do You Need More T Cells to Stop Type 1 Diabetes?

A novel treatment meant to stop Type 1 diabetes by increasing the number of T cells in the body is being given special attention by the FDA. The treatment, called CLBS03, has recently been granted Fast Track status by federal regulators, a designation which speeds up the approval process.

NHS – Ibuprofen-like painkillers linked to an increased risk of heart failure

New research suggests that taking painkillers known as non-steroidal anti-inflammatory drugs (NSAIDs) – which includes ibuprofen – increases the risk of heart failure by less than 20% overall. NSAIDs are a group of painkilling medicines commonly taken by people with joint problems, backache and arthritis. They are prescribed to relieve pain and reduce inflammation.

Possible New Benefit For Metformin Users

Many people with type 2 diabetes take the drug metformin to control their blood sugar levels. But now, new research suggests that his drug may also benefit type 1 diabetics, by slowing down the progression of heart disease.

NPR – After Medical Marijuana Legalized, Medicare Prescriptions Drop For Many Drugs

Research published Wednesday found that states that legalized medical marijuana — which is sometimes recommended for symptoms like chronic pain, anxiety or depression — saw declines in the number of Medicare prescriptions for drugs used to treat those conditions and a dip in spending by Medicare Part D, which covers the cost on prescription medications.

Invokana Superior As Second Add-on to Metformin

Over a one-year study, glycemic control was improved and body weight and blood pressure were reduced with Invokana® (canagliflozin, Janssen) as add-on therapy to metformin in patients with type 2 diabetes, according to a presentation at AACE.

Victoza Reduces Cardiovascular Death by 22% in Type 2 Diabetes

GLP-1 Victoza reduces the risk of death from heart disease, kidney disease, hypoglycemia, severe hypoglycemia, and other complications in people with type 2 diabetes at high risk for heart disease.

Researchers Testing SGLT2 Drugs for Type 1 Use

Pharma companies are testing whether drugs designed for combatting Type 2 diabetes can be used to also treat Type 1 diabetes. The latest attempt involves a class of of oral antidiabetics called SGLT2 inhibitors, first cleared by the Food and Drug Administration on March 29, 2013.

Drug Duo Might Reduce Risk Of Death In Type 2 Diabetics

Type 2 diabetic patients who took both insulin and metformin showed a reduced risk of death and cardiac events compared with people treated with insulin alone, according to a new study conducted by researchers at Cardiff University.

Testing Metformin to Prevent Type 1 Diabetes

Last November, JDRF officials announced that researchers had found biological markers for Type 1 diabetes long before symptoms appeared in children. Now another group of researchers hope to see if they can prevent Type 1 before children become symptomatic, and to do it they are planning to use a classic tool in diabetes management – […]

9 Things We Learned About Afrezza’s Future

It was supposed to be a great marriage of a new product and deep pockets. In 2014, the pharmaceutical giant Sanofi agreed to market Afrezza, an inhalable insulin created by Mannkind Corporation. It didn’t work out that way.

Metformin is Safe for Over 1 Million More People with Type 2 Diabetes

The FDA recently released a Drug Safety Communication announcing revisions to metformin’s label to expand use in people with type 2 diabetes and mild to moderate kidney (renal) impairment. Previously, the FDA advised against using metformin (Glucophage, Glumetza, Riomet, and Fortamet) in this group.