Drugs

FDA Approves New Diabetes Combo LixiLan and IDegLira for T2 Diabetes

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Both products, known as LixiLan and IDegLira during clinical trials, were delayed by 3 months at the U.S. Food and Drug Administration (FDA) following recommendations for approval from FDA panels back in May. And yet the FDA has approved the two new competing combination products containing fixed doses of glucagonlike-peptide 1 (GLP-1) receptor agonists and […]

Long-acting Synjardy gets FDA approval for type 2 diabetes treatment in the US

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The US Food and Drug Administration (FDA) has approved the slow release form of Synjardy. Synjardy is a drug used by people with type 2 diabetes in the UK as a twice daily single pill combination therapy to lower blood sugar levels.

Joslin Diabetes – Is it Possible to Get Diabetes from Statins?

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If you’re like nearly one-third of Americans over age 40, you probably take a statin. These cholesterol-lowering drugs are used for reducing risk of stroke and heart attack. They work by lowering the amount of LDL cholesterol, the so-called “bad cholesterol” in the blood. Statins also reduce inflammation around plaque in the blood vessels.

Can Statins Offset Insulin-Related Cancer Risk in T2DM?

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The researchers found that the risk of cancers of the colon (males only), liver (males only), pancreas, lung (males only), and brain (males only) were increased up to nine-fold for patients treated with insulin or insulin secretagogues; the risk of prostate cancer was decreased strongly. The risks were generally decreased for patients taking statins, with […]

Trial finds type 2 diabetes drug liraglutide can affect heart rate variability

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The type 2 diabetes drug liraglutide could affect heart variability in newly diagnosed people who are overweight and have heart problems, according to new research. Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist which helps control blood sugar levels and reduces post-meal hyperglycemia. The drug is marketed as Victoza and Saxenda.

Diabetes Mine – Media Matters: The Feud Over Heart Risk Lowering Diabetes Drugs

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Believe it or not, some people were disappointed and underwhelmed by solid evidence that Victoza (ligratude), a medication for type 2 diabetes, reduces the risk of fatal diabetes complications. That news, based on a massive clinical trial of Novo Nordisk’s drug, was one of the mostly widely reported items from the American Diabetes Association’s recent […]

Do You Need More T Cells to Stop Type 1 Diabetes?

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A novel treatment meant to stop Type 1 diabetes by increasing the number of T cells in the body is being given special attention by the FDA. The treatment, called CLBS03, has recently been granted Fast Track status by federal regulators, a designation which speeds up the approval process.

NHS – Ibuprofen-like painkillers linked to an increased risk of heart failure

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New research suggests that taking painkillers known as non-steroidal anti-inflammatory drugs (NSAIDs) – which includes ibuprofen – increases the risk of heart failure by less than 20% overall. NSAIDs are a group of painkilling medicines commonly taken by people with joint problems, backache and arthritis. They are prescribed to relieve pain and reduce inflammation.

Possible New Benefit For Metformin Users

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Many people with type 2 diabetes take the drug metformin to control their blood sugar levels. But now, new research suggests that his drug may also benefit type 1 diabetics, by slowing down the progression of heart disease.

NPR – After Medical Marijuana Legalized, Medicare Prescriptions Drop For Many Drugs

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Research published Wednesday found that states that legalized medical marijuana — which is sometimes recommended for symptoms like chronic pain, anxiety or depression — saw declines in the number of Medicare prescriptions for drugs used to treat those conditions and a dip in spending by Medicare Part D, which covers the cost on prescription medications.

Invokana Superior As Second Add-on to Metformin

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Over a one-year study, glycemic control was improved and body weight and blood pressure were reduced with Invokana® (canagliflozin, Janssen) as add-on therapy to metformin in patients with type 2 diabetes, according to a presentation at AACE.

Victoza Reduces Cardiovascular Death by 22% in Type 2 Diabetes

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GLP-1 Victoza reduces the risk of death from heart disease, kidney disease, hypoglycemia, severe hypoglycemia, and other complications in people with type 2 diabetes at high risk for heart disease.

Researchers Testing SGLT2 Drugs for Type 1 Use

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Pharma companies are testing whether drugs designed for combatting Type 2 diabetes can be used to also treat Type 1 diabetes. The latest attempt involves a class of of oral antidiabetics called SGLT2 inhibitors, first cleared by the Food and Drug Administration on March 29, 2013.

Drug Duo Might Reduce Risk Of Death In Type 2 Diabetics

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Type 2 diabetic patients who took both insulin and metformin showed a reduced risk of death and cardiac events compared with people treated with insulin alone, according to a new study conducted by researchers at Cardiff University.

Testing Metformin to Prevent Type 1 Diabetes

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Last November, JDRF officials announced that researchers had found biological markers for Type 1 diabetes long before symptoms appeared in children. Now another group of researchers hope to see if they can prevent Type 1 before children become symptomatic, and to do it they are planning to use a classic tool in diabetes management – […]

9 Things We Learned About Afrezza’s Future

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It was supposed to be a great marriage of a new product and deep pockets. In 2014, the pharmaceutical giant Sanofi agreed to market Afrezza, an inhalable insulin created by Mannkind Corporation. It didn’t work out that way.

Metformin is Safe for Over 1 Million More People with Type 2 Diabetes

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The FDA recently released a Drug Safety Communication announcing revisions to metformin’s label to expand use in people with type 2 diabetes and mild to moderate kidney (renal) impairment. Previously, the FDA advised against using metformin (Glucophage, Glumetza, Riomet, and Fortamet) in this group.

Wired – TII Diabetes Drug That Also Treats Obesity Could Make Billions

Drugs

Earlier this month, at the Endocrine Society’s annual conference in Boston, Danish pharma Novo Nordisk presented three years of data showing that their diabetes drug liraglutide helped obese and prediabetic patients lose weight without undue risk. Which is big, for a drug that’s been flagged for causing cancer.

Metformin for Overweight Teens with Type 1?

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A recent study found that metformin might help overweight teens with Type 1 diabetes lower their A1C scores. Metformin, an oral medication that’s prescribed to treat Type 2 diabetes, helped the teens lower their insulin resistance.

Use of SGLT-2 Inhibitors Combo with Metformin for Greater Glycemic Control

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For patients with elevated HbA1c, the use of combination antihyperglycemic medications after inadequate control with metformin alone is commonly prescribed to help patients achieve individualized glycemic levels. Is there actual benefit in dual therapy treatment? Study looks at canagliflozin plus metformin.