Drugs

Newer Type 2 Drugs Increase Out-of-Pocket Costs for Medicare Patients

Recent diabetes guidelines have suggested giving type 2 diabetes patients newer glucose-lowering drugs like SGLT2 inhibitors, GLP-1 agonists, and DPP-4 inhibitors, earlier in preference to older drugs like metformin and the sulfonylureas, due to their many benefits. However, for Medicare recipients, the out-of-pocket costs for these drugs are much higher. Read more

SGLT2 Inhibitors May Delay Kidney Disease

Drugs from the SGLT2 inhibitor class of diabetes medications have shown benefit in slowing progression of diabetic kidney disease, with a reduced risk of acute kidney injury (AKI) noted in research trials. People at high risk of AKIs who may be considering SGLT2 treatment should discuss the risks and benefits with their doctors. Read more

FDA Approves New Trulicity Dosages

The FDA has approved 2 additional doses of Eli Lilly’s Trulicity (dulaglutide) for treating type 2 diabetes. The approval of the new 3.0 mg and 4.5 mg doses of dulaglutide was based on clinical trial results showing benefits for A1C levels and weight loss. Read more

Metformin Helps Reduce Presurgical Stress

Surgical procedures cause both physical and mental stress on patients, and higher stress level is associated with an increased risk of complications and death. Researchers examined the effectiveness of metformin use before surgeries to reduce the risk of complications in patients with type 2 diabetes. Read more

Can Diabetes Drugs Fight COVID-19?

Multiple diabetes drugs are undergoing trials to see if they have a role to play in the fight against the novel coronavirus COVID-19. It’s already known that people with diabetes are at higher risk of serious complications from COVID-19; one reason may be that COVID-19 attacks the same bodily systems damaged by type 2 diabetes […]

Assessing the Heart Benefits of Ertugliflozin

The results from a major trial examining whether the diabetes drug ertugliflozin (brand name STEGLATRO), the VERTIS-CV trial, suggest that ertugliflozin is not superior to placebo in reducing major adverse cardiovascular events (MACE) but may reduce the rate of hospitalization for heart failure.  Read more

FDA Removes Amputation Warning for Invokana

Based on recent review of studies showing that the diabetes drug canagliflozin (Invokana) has many benefits for heart and kidney disease, and that the risk of amputation, while still increased with canagliflozin, is lower than previously described, the FDA has concluded that the boxed warning for increased amputation risk should be removed.  It is still important […]

A New “Heat-Tethered” Method of Dual Drug Administration

Researchers from Duke University have demonstrated that a type 2 diabetes treatment combining two drugs is more effective when the drugs are linked by a heat-sensitive tether, instead of simply being administered at the same time. Read more

Dapagliflozin Approved to Treat Heart Failure

The DAPA-HF trial provided evidence for improved mortality and morbidity benefits when using the diabetes drug dapagliflozin, in combination with normal standards of care, for patients with heart failure and reduced left ventricular fraction. Read more

Bayshore Pharmaceuticals Joins Metformin Recall List

Bayshore becomes the sixth pharma company to issue a recall for the popular diabetes drug metformin, after the FDA found high levels of N-nitrosodimethylamine (NDMA), a probably carcinogen, in tested samples. The recall is for one lot each of the 500- and 750-milligram extended-release metformin. Read more

DPP-4 Inhibitors Linked to Rare Skin Condition

Researchers say that the class of diabetes drugs called DPP-4 inhibitors, which includes include sitagliptin, saxagliptin, linagliptin, and alogliptin, may be linked to a rare skin condition called bullous pemphigoid, which causes large, fluid-filled blisters due to an abnormal immune system response. Read more

FDA “Fast-Tracks” Farxiga for Heart Failure Benefits

Research has shown that diabetes drugs in the SGLT2 inhibitor class can have cardiovascular benefits. Now the FDA has given a Fast Track Designation to accelerate study of how one of these drugs, Farxiga (dapagliflozin) may help reduce death and heart failure after a heart attack. Read more

Statins Reduce Mortality Risk in Older Patients

Heart disease is more life-threatening in older patients than younger population or middle-aged patients. Prevention strategies, including using lifestyle modification and statins, are gaining increasing importance among physicians. A study on statin use in veterans 75 years or older found that statins were associated with overall reduced risk of disease and death. Read more

Oral Semaglutide Effective Paired with Insulin

Multiple studies have been conducted to evaluate the performance of oral semaglutide, which is the first oral medication in the glucagon-like peptide-1 (GLP-1) receptor agonist drug class. The PIONEER 8 trial found reductions in A1c and body weight when oral semaglutide is paired with various insulin regimens. Read more

ACE Inhibitor Captopril May Cause Problems in COVID-19

Captopril, an ACE inhibitor drug, seems to be associated with a higher rate of adverse pulmonary reactions in patients with diabetes than other ACE inhibitors or angiotensin receptor blockers (ARBs). ACE inhibitors are commonly used to treat heart and kidney conditions, which are often comorbid with diabetes. A different ACE inhibitor may be a better […]

Who Should Take Metformin?

A new study examined randomized trials of glucose-lowering drugs, including SGLT2 inhibitors and GLP-1 agonists, and assessed drug effectiveness for four categories of patients: diabetes drug-naive or those taking metformin at low or high risk of cardiovascular disease (CVD). Read more

Alzheimer’s Drugs Could Help Prevent Blood Vessel Damage

Drugs originally developed to treat Alzheimer’s Disease could be re-purposed to prevent, or possibly even reverse, the damage done to the blood vessels in people who have obesity or type 2 diabetes, researchers say. Both type 2 and obesity can contribute to stiffening of blood vessels, which increases risk for heart attack or stroke. Read […]

Could Trulicity Help Prevent Dementia?

Recent research into the glucagon-like peptide-1 (GLP-1) receptor agonist drug dulaglutide (Trulicity) suggest it may lower cognitive decline in type 2 diabetes, possibly in association with reduced risk of stroke associated with the drug. Read more

New Insight into How Metformin Works

A new study shows that metformin, a common type 2 diabetes drug, may have a previously unknown mechanism of action, involving the release of sugars in the blood from the intestines into the stool. Better understanding of how metformin works could eventually lead to development of new and improved diabetes medications.  Read more

Consumer Advocacy Group Wants SGLT-2 Warnings for Type 1 Patients

Public Citizen, a consumer advocacy group, is urging the FDA to strengthen its warnings that SGLT-2 inhibitors are associated with increased risk of diabetic ketoacidosis, due to hundreds of cases of this potentially fatal condition in people with type 1 diabetes. SGLT-2 inhibitors are not currently approved for use in type 1 diabetes in the […]