Glucose & Insulin

Zegalogue Glucagon Rescue Pen Receives FDA Approval

Zegalogue will be sold as both an auto-injector, similar to an EpiPen, and a prefilled syringe, and will allow people with diabetes to quickly raise their blood sugars in an emergency situation. It is approved for adults and for children 6 and up, and is expected to launch in June 2021. Read more

ADA Urges Stricter A1c Guidelines for Children with Type 1

The American Diabetes Association (ADA) recommends lowering the target hemoglobin A1C (HbA1C) guidelines for children with type 1 diabetes. This is due to the finding that chronically high blood glucose levels in children could lead to higher risk of several serious effects, including abnormal brain development and cardiac issues. Read more

No-Refrigerator Insulin in Development

Aiotech company called Thermalin is working on a new type of ultra-fast insulin that will not require refrigerated storage. They are also developing a miniaturized closed loop device (also called an artificial pancreas system) called the StampPump. Read more

COVID-19 Severity Linked to Hyperglycemia

COVID-19 patients may be at a higher risk for complications and death if their blood glucose is elevated, even if they have not been diagnosed with diabetes, researchers say. Read more

Telemonitoring as Tool for Diabetes Care

Diabetes patients who used a medical device an software system called DIABEO to help manage their insulin dosage were more successfully able to reduce their HbA1c levels, a study found, since using the telemonitoring system allowed patients more support and guidance on controlling their glucose levels. Read more

High Glucose Can Damage the Brain

Uncontrolled blood glucose in diabetes can lead to numerous debilitating complications, including high blood pressure, strokes, slow wound healing, and possibly amputations. Researchers have found that brain damage can also result from uncontrolled type 2 diabetes. Read more

Can Electromagnetic Fields Treat Diabetes?

Electromagnetic fields (EMFs) might be a safe and non-invasive way to manage blood glucose in diabetes, say researchers who examined the effects of EMFs in altering the balance of oxidants and antioxidants in the liver and causing an improvement in the body’s response to insulin. Read more

Anemia and A1c

Glycated hemoglobin (A1c) testing is a standard method of assessing blood glucose levels in people with diabetes. However, researchers are finding that iron deficiency or vitamin B12 deficiency anemia can affect A1c testing results. Read more

The Role of Weak and Strong Cells in Insulin Production

Type 2 diabetes is the condition that results when β-cells (beta cells) cannot release enough insulin for the body’s needs. A group of researchers say they have new insight into how “weak” beta cells bond with other, more mature cells to boost insulin production, which can help us understand more about the processes that lead […]

The Long-Term Risks of Severe Hypoglycemia

Severe hypoglycemia can lead to fatal complications, including heart arrhythmias, seizures, and coma. Research has also found that patients with hypoglycemic events severe enough to require medical assistance also had increased risk of developing cancer and skin, respiratory, and digestive complications. Read more

Add-on Therapy Can Reduce Insulin Use for Type 2 Patients

Insulin is the mainstay treatment for patients with type 2 diabetes who also have beta-cell failure; however, some insulin regimens can be complicated to manage and may increase the risk of hypoglycemia. Now, researchers say that a simple add-on therapy with the GLP-1 Agonist medication albiglutide can reduce insulin use for patients with type 2 […]

Potential New Target for Diabetes Treatment

Researchers have discovered a new insulin inhibitory receptor, named inceptor. (Insulin receptors are areas in human cells that allow insulin in the blood to join or bind with the cell.) The researchers found that blocking inceptor function makes the insulin signaling pathway in pancreatic beta cells more sensitive, which could potentially allow protection and regeneration […]

Metabolic Memory Makes Effects of Poor Glucose Control Persist

Prolonged hyperglycemia can lead to complications that damage the eyes, kidneys, nervous system, and cardiovascular system. The effects can be permanent and cause further damage, even if blood glucose levels are reduced. This is called metabolic memory, and is reason to control blood glucose levels sooner rather than later. Read more

Daily Pill Could Help Optimize Insulin Use

New studies have investigated a once-daily pill that can optimize insulin therapy and reduce HbA1c among adults with type 1 diabetes. The pill, a novel liver-selective glucokinase activator, also known as TTP399, showed superior A1c reduction compared to placebo. Read more

Endoscopic Procedure Could Reduce Insulin Dependence

A small trial found that an endoscopic therapeutic procedure, which involved putting a small balloon filled with hot water down the patient’s throat, successfully reduced the need for insulin use in most participants. The procedure burns away some of the small intestine’s surface cells which are then replaced; the new cells signal the body to […]

Insulin & Glucagon Together Reduce Hypoglycemia Risk

Hypoglycemia is a major risk for people with diabetes on insulin-containing regimens. These risks are even greater in those taking beta-blockers, as symptoms of low blood sugar can be masked by the drug. However, administering insulin with glucagon may help to reduce the risk, researchers say. Read more

Good Glucose Control Helps Reduce Coronavirus Risks

People with diabetes are at greater risk for severe complications of COVID-19, but researchers say people with well-controlled blood glucose levels, defined as 70-72mg/dL.(3.9-10 mmol/L), have better COVID-19 treatment outcomes.  Read more

An Intestinal Film to Block Glucose Uptake

Researchers at Massachusetts Institute of Technology (MIT) have developed a new synthetic film that could help manage diabetes. The material would be consumed as a liquid; the film has the ability to self-assemble in the intestine to block the absorption of glucose, and subsequently dissolve. Read more

Insulin Challenges for Many Amid COVID-19 Pandemic

People with diabetes are at higher risk for complications of COVID-19, and good diabetes management is key for maximizing health and reducing risk. But for many with type 1, obtaining insulin is a challenge due to job and health insurance losses in the pandemic. Read more

Glucose Management Helps Reduce Cognitive Decline Risk

As people age, obesity and diabetes put them at higher risk for cognitive conditions like Alzheimer’s Disease. Type 2 diabetes damages the brain regions that govern memory, movement, and visual processing, but maintaining good glucose levels can help reduce the risk. Read more