Medical Research

New-Onset Diabetes After Kidney Transplant

New-onset diabetes after transplantation (NODAT) is a common complication after kidney transplantation, but its mechanism is not fully understood. Researchers in South Korea conducted a study that suggests gut microbiota play a role in the development of NODAT in kidney transplant recipients. Read more

New Research Network to Study Diabetic Foot Ulcers

Six U.S. research institutions are launching a multicenter network, the Diabetic Foot Consortium (DFC), funded by the National Institutes of Health, to study diabetic foot ulcers. Foot ulcers are a common diabetes complication and the leading cause of lower limb amputations in the U.S., and this is the first research network dedicated to studying how […]

“Metabolic Memory” of Poor Glucose Control Can Last a Lifetime

Researchers have found a strong association between early episodes of poor blood sugar control, epigenetic changes (which affect the activity of particular genes without altering their DNA sequences), and diabetic complications years later, even if patients subsequently had better glycemic control. Read more

Long Term Effects of Gastric Bypass & Type 2

A large study of people with type 2 diabetes who had gastric bypass surgery found that their risks for all-cause mortality, cardiovascular disease, acute myocardial infarction, and congestive heart failure were all lower after the surgery. They also had reduced risk of kidney disease, hyperglycemia, cancer, and leg amputations. However, there were also some negative […]

Passive Stretching May Help Prevent Diabetes, Heart Disease

A new study has found passive stretching helps improve blood flow, making it easier for your arteries to dilate and decreasing their stiffness. These findings could have implications for diseases like diabetes and heart disease that involve impaired vascular systems. Read more

Preventing Type 1 May Become a Reality

Teplizumab may become the first antibody commercially available that can halt or delay the progression of type 1 diabetes. Researchers have found that a single 14-day infusion of teplizumab leads to a median 3-year delay in type 1 diabetes onset in high-risk individuals. Read more

Glycemic Control in Young Americans with Diabetes Getting Worse

Blood glucose control among youth with diabetes has not improved since 2002 levels, and has actually gotten worse in some subgroups, according to data presented at the virtual American Diabetes Association (ADA) 2020 Scientific Sessions. This is despite increased availability of diabetes technology and new therapies in recent decades, and despite more aggressive recommended blood […]

Vitamin A Analog May Help Treat Diabetic Retinopathy

Diabetic retinopathy, a common complication of diabetes, is a major cause of blindness in adults. A new study found that visual function in diabetic mice was significantly improved after treatment with a single dose of visual chromophore 9-cis-retinal, a vitamin A analog that can form a visual pigment in the retina cells, thereby producing a […]

“Urgent Need” for More Black Participants in Clinical Trials

Black Americans must be recruited more actively for clinical trial participation, a researcher urges. Data from diabetes clinical trials show that findings often do not apply to blacks and other ethnic minorities in the same way they do to white diabetes patients. Read more

Is Premature Birth Linked to Diabetes Risk?

A new study investigated whether being born prematurely can raise a person’s risks of developing either type 1 or type 2 diabetes from childhood into early to mid-adulthood. Read more

How Gender Impacts Vascular Disease

Both men and women are affected by diabetes, but previous studies have found that women are more affected by macrovascular complications such as coronary artery disease and stroke. It’s not yet known why this is, but the different ways male and female bodies store fat may play a role. Read more

Cortisol Levels May Predict Hypertension, Diabetes

Obesity is a risk factor for many conditions, including type 2 diabetes. Now researchers say obesity may be a result of an alteration in the hypothalamic-pituitary-adrenal (HPA) axis. A recent study examined cortisol levels in people with obesity to determine if there is an association with diabetes, hypertension, and cortisol. Read more

A1c Levels Can Indicate Coronary Arterial Plaque

The results of a recent study strengthen the theory that HbA1c is associated with coronary atherosclerosis development, a forerunner of heart disease, in people who do not have diabetes. Mixed patterned plaques were found to be more associated with higher HbA1c levels. Read more

Reversing Diabetes with Gene Editing

Scientists at Washington University announced they have developed a way to use gene editing system CRISPR-Cas9 to edit a mutation certain stem cells and then turn them into beta cells that produce insulin. When transplanted into mice, the cells reversed preexisting diabetes. Read more

Genetic Dyslipidemia and Type 2

Previous studies have had conflicting results on whether patients with familial combined hyperlipidemia (FCHL) — a form of dyslipidemia that results in abnormally high levels of lipids — had a higher incidence of type 2 diabetes. Now a 15-year study has found patients with FCHL are a significantly higher risk for developing type 2 diabetes. […]

Air Pollution Increases Diabetes Risk

Exposure to air pollution alters gut microbiome composition, which subsequently increases the risk of obesity, diabetes, and other chronic illnesses, according to a new study which used whole-genome sequencing to examine whether air pollutants affected the gut microbiome of 101 young adults. Read more

Potential Diabetes Cure Coming Closer

Converted human stem cells cured mice with diabetes for at least nine months and, in some cases for a year. The transformed cells produced insulin, allowing the mice to decrease their high blood sugars. While the research is still in early stages, the researchers feel it holds promise. Read more

Type 1 Diabetes May be Two Distinct Conditions

New research has found that children diagnosed with type 1 diabetes under the age of seven have a different type (specifically “endotype”) of the condition compared to patients with diabetes who have been diagnosed at age thirteen or above. These findings could spur further research into whether dormant insulin-producing cells can be reactivated.  Read more

Duodenal Mucosal Resurfacing: A Less-Invasive Take on Bariatric Surgery

Bariatric surgery has been increasingly used in patients with obesity, and is an effective way to help aid glycemic control. It has been suggested that changing how nutrients are presented to the duodenum is one reason why improvements are seen after bariatric surgery. Importantly, this alteration does not appear to lead to malabsorption of nutrients. […]

Coin-Sized Smart Insulin Patch Could Help Treat Diabetes

Researchers have made progress in developing a smart insulin-delivery patch that may one day monitor and manage glucose levels in people with diabetes, and deliver the necessary insulin dosage. The adhesive patch is about the size of a quarter, is simple to manufacture, and is intended for once-a-day use. Read more